Saturday, October 19, 2013

Ben Foster cycles ahead on Lance Armstrong movie

LONDON (AP) — American actor Ben Foster is cycling into the lead as Lance Armstrong in a new movie about the disgraced American cyclist.


Director Stephen Frears said filming started Wednesday on the untitled project, and Foster is already proving to be a champion in the saddle.


Frears claims Foster is a "really, really good actor and now he's a very good cyclist. The cyclists were pleased with him."


The movie follows the rise of Armstrong, his cancer battle, retirement and exposure by journalist David Walsh.


Irish star Chris O'Dowd plays Walsh, with Guillaume Canet and Jesse Plemons in supporting roles.


Frears says Armstrong is endlessly complex and there could be many more films made about him. He spoke at Wednesday's London Film Festival gala for his latest movie, "Philomena," staring Judi Dench.


Source: http://news.yahoo.com/ben-foster-cycles-ahead-lance-armstrong-movie-101157671.html
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Friday, October 18, 2013

Which Grandparent Are You Most Related to?

Illustration by Robert Neubecker.

Illustration by Robert Neubecker








What makes you who you are genetically? The easy answer is your family. The longer answer begins with the fact that all humans have two parents (at least for now), and usually four distinct grandparents (there are unfortunate exceptions). Genetically you are a recombination of four separate individuals. But that does not mean you have an equal contribution from four separate individuals. Humans normally carry 23 pairs of chromosomes: 22 autosomal pairs and one pair of sex chromosomes, either two copies of the X for a female or an X and a Y in the case of males. By Mendel’s law of segregation you receive one copy of each pair from your mother (via the egg), and one copy from your father (via the sperm). This means exactly half of your genome derives from each parent.














Things begin to get more complicated going back two generations. One might think that of the 44 autosomal chromosomes you would receive 11 from each of the four grandparents. (For simplicity we’ll leave the sex chromosomes out for now. If you are a female, you receive one X from each parent, while if you are a male you receive an X from your mother and a Y from your father, who got it from his father.) But while the proportion of one’s inheritance from parents is fixed by exact necessity, the fraction from grandparents is governed by chance. For each of the chromosomes you inherit from a given parent, you have a 50 percent chance of gaining a copy from your grandfather and a 50 percent chance of gaining a copy from your grandmother. The laws of independent probability imply that there is a 1 in 4 million chance that all of your maternal or paternal chromosomes could come from just one grandparent!* What’s more, genetic recombination means that chromosomes aren’t purely from one grandparent or the other; during the cell divisions that produce sperm and eggs, chromosomes exchange segments and become hybrids. You almost certainly have different genetic contributions from your four grandparents.










But this is not just abstract theorizing. Imagine that you could know that 22 percent of the genome of your child derives from your mother, and 28 percent from your father. Also imagine that you know that 23 percent of the genome of your child derives from your partner’s mother, and 27 percent derives from your partner’s father. And you could know exactly how closely your child is related to each of its uncles and aunts. This isn’t imaginary science fiction, it is science fact.












Last year, I sent a sample of my then 2-month-old daughter’s genetic material to the firm 23andMe and received her results. As it happens I already had the genotype of my daughter’s mother, father, all her uncles and aunts, and all four of her grandparents. In other words, her full pedigree was already available when her results came back, and she was easily slotted into the bigger genomic family photo album. Not only do I know which proportions of her ancestry derived from each grandparent, I know which regions of her genome derive from each of her grandparents. For example, one grandmother is half Norwegian, so genealogically my daughter isone-eighth Norwegian. But I quickly calculated using diverse data sets of various nationalities that genomically she is somewhat more than one-eighth Norwegian. This is reasonable as 28 percent of her ancestry, according to how her DNA analysis matches up with the DNA of the rest of the family, happens to come from her half Norwegian grandmother.










One might think these sorts of facts are useful only for the sake of satisfying curiosity, but sometimes theoretical knowledge can be put to practical use. Last spring my wife asked our pediatrician about testing my daughter for a treatable autosomal dominant condition which I happen to exhibit. The physician’s reaction was straightforwardly paternalistic. She would not authorize the test because she believed our daughter was too young. This did not sit well with my wife. The mutated gene which causes my condition has been well characterized. My wife went home and quickly used one of 23andMe’s features to find out if my daughter inherited a copy of the gene through me from my mother or my father. My mother is affected by the same ailment as I am, while my father is not. The happy ending is that my daughter almost certainly does not have the condition, because she inherited that genetic region from my father. The bigger moral of the story is that decentralized genetic information can allow persistence to pay off.










All of this is a consequence of the fact that I have an obsession with genetics. But it is also contingent on the fact that for less than $500, you can send in a kit and receive back a record of 1 million genetic variants in short order. This would have been unfathomable just 10 years ago. Out of 3 billion base pairs in the entire human genome, 1 million may not seem like much, but the ones tested were chosen because they vary across the population, and they represent a substantial proportion of the variable genome. Much of the information is banal, trivial, and redundant. My eyes are dark brown, and those of my wife are blue. Therefore, you will not be surprised to learn that a quick check on variants that code for eye color predicts that my daughter will shake out to have a light brown shade (as a matter of fact her eyes are light brown or hazel).


















Source: http://www.slate.com/articles/health_and_science/human_genome/2013/10/analyze_your_child_s_dna_which_grandparents_are_most_genetically_related.html
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Saudi Arabia rejects seat on UN Security Council

DUBAI, United Arab Emirates (AP) — Saudi Arabia on Friday rejected its seat on the U.N. Security Council hours after it was elected to it, in a rare and startling move aimed at protesting the body's failure to resolve the Syrian civil war.


The Saudi discontent appeared largely directed at its longtime ally, the United States, reflecting more than two years of frustration. The two are at odds over a number of Mideast issues, including how Washington has handled some of the region's crises, particularly in Egypt and Syria. It also comes as ties between the U.S. and Iran, the Saudi's regional foe, appear to be tepidly improving.


Saudi Arabia showed its displeasure last month when Saudi Foreign Minister Saud al-Faisal declined to address the General Assembly meeting. Days later, the kingdom's unease with Washington appeared to manifest when President Barack Obama spoke to Iran's new President Hassan Rouhani in a groundbreaking telephone call.


The kingdom was given one of the rotating seats on the 15-member council in a vote Thursday.


On Friday, the Saudi Foreign Ministry issued a statement rejecting the seat, saying the U.N. Security Council had failed in multiple cases in the Middle East. Particularly, it said U.N. failure to act has enabled Syrian President Bashar Assad's regime to perpetrate the killings of its people, including the use of chemical weapons. The Syrian regime denies using chemical weapons.


"Allowing the ruling regime in Syria to kill its people and burn them with chemical weapons in front of the entire world and without any deterrent or punishment is clear proof and evidence of the U.N. Security Council's inability to perform its duties and shoulder its responsibilities," the ministry said in the statement carried on the state news agency.


Saudi Arabia backs the rebels fighting to overthrow Assad in a war that has killed some 100,000 people since early 2011. Repeated attempts by the U.N. Security Council to address the conflict have fallen apart, usually because Assad's ally Russia has blocked strong resolutions. Still, in a rare consensus, the council passed a resolution on destroying Syria's chemical arsenal after an Aug. 21 chemical attack.


Saudi Arabia and other Sunni Arab leaders have backed the Syrian rebels with weapons and financing in part to counter their regional rival Iran, which has strongly thrown its weight behind its ally, Assad. At the same time, the friendly gestures between the U.S. and Iran's new government have made Saudi Arabia uneasy.


Russia said it was "surprised" and "baffled by the reasons that the kingdom gave to explain its position" — particularly after the chemical weapons resolution. That resolution was passed after Russia brokered Damascus' consent to surrender its chemical arsenal, which it had long kept secret.


There appear to be some efforts under way to get the Saudis to recant. Britain's deputy U.N. ambassador Peter Wilson told reporters his team is looking at what precisely the Saudis meant by their statement and are talking to them "to get a little bit more background on what lies behind this."


U.N. Secretary-General Ban Ki-moon said he has "taken note" of the media reports of the Saudi rejection, "but I would like to caution you that I have received no official notification in this regard."


"We also are looking forward to working very closely in addressing many important challenges with the Kingdom of Saudi Arabia," particularly the Syrian war and other issues, including combatting "terrorism and nuclear proliferation," he said.


He said member states are holding discussions on how to deal with the Saudi move. Ban talked to a senior official in the Saudi government after the news broke, a U.N. official said, speaking on condition of anonymity because the discussion was private.


U.N. diplomats and officials said the Saudi rejection of the seat appears to be unprecedented. U.N. spokesman Martin Nesirky said U.N. officials were going back through Security Council records to check whether this was the first time a nation rejected a seat.


The Saudi Foreign Ministry statement was a sharp change in tone from comments by the kingdom's U.N. ambassador the day before. At the time, Abdallah Al-Mouallimi said his country's election to the council was "a reflection of a longstanding policy in support of moderation and in support of resolving disputes by peaceful means."


He also said his country takes its election "very seriously as a responsibility."


The Saudi statement Friday also blamed the Security Council for failing to transform the Middle East into a zone free of weapons of mass destruction — a reference to Israel, which has never confirmed or denied possession of nuclear weapons. It also said the Council has not been able to resolve the Palestinian-Israeli conflict over the past six decades.


While Saudi Arabia and the United States share core strategic interests regarding mutual worries over Iran, cooperation in counter-terrorism and support for Syria's rebels, they have differed in their approach.


Most recently Saudi Arabia's leaders were furious when the United States pulled back from possible military action against the Syrian regime in exchange for the Russian plan to dismantle Syria's chemical arsenal.


Editorials in Arabic newspapers over the past several weeks have reflected the Gulf's concerns. In an opinion piece published in the Al-Hayat daily Arabic newspaper, columnist George Samaan wrote that if the Gulf states feel Washington is turning its back on them by improving ties with Iran, the Arab states could always look east to other countries.


Another columnist, Abdel-Rahman el-Rasahd, wrote in Al-Sharq Al-Awsat daily that rather than Obama striking the Syrian regime, he struck U.S. allies by calling Iran's president and pushing Gulf states to pursue their own defense policies.


Washington-based analyst Frederic Wehrey said the recent U.S.-Iranian overtures were a "shock" to Saudi rulers..


"It's not really a question that the U.S. is pursuing relations with Iran, but that Saudi Arabia feels left out in the cold," said Wehrey of the Carnegie Endowment for International Peace. They felt "the rug had been pulled out from under them" and saw it as American "betrayal."


The kingdom easily won the Security Council seat in Thursday's vote in New York, facing no opposition because there were no contested races for the first time in several years. The Council seats are highly coveted because they give countries a strong voice in matters dealing with international peace and security, in places like Syria, Iran and North Korea, as well as the U.N.'s far-flung peacekeeping operations.


Saudi Arabia was nominated by the Asia group for an Arab seat on the council, so Asian nations would have to select a new candidate — or candidates. The entire 193-member General Assembly would then have to hold another election to choose a new council member.


The 15-member council includes five permanent members with veto power — and 10 nonpermanent members elected for two-year terms.


__


Lederer reported from the United Nations in New York. AP correspondents Abdullah al-Shihri in Riyadh, Saudi Arabia; Nataliya Vasilyeva in Moscow; and Maamoun Youssef in Cairo contributed to this report.


Source: http://news.yahoo.com/saudi-arabia-rejects-seat-un-security-council-090849059.html
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All Is Well Between Miley And The Little People




By Travis October 18, 2013 @ 9:00 AM




Last week, one of the little people employed by Miley Cyrus as a backup dancer complained that she felt exploited for having accepted money from the twerking singer to dress up as a bear and dance on stage. Of course, this was stupid, because fuck you, you were paid to do a job, you did it and you’ll do it again any time someone hands you a signed check. But Miley still wants people to know she’s not a heartless monster with an elementary school sense of humor, so she Tweeted this picture last night of her and the dwarven dancers having a slumber party and braiding each other’s hair.


Sure, minutes later she probably threw one of them into a mud pit before firing a pistol into the air and shouting, “Midget huntin’, y’all!” but the bottom line is that Miley still loves her bitches.




Source: http://www.wwtdd.com/2013/10/all-is-well-between-miley-cyrus-and-the-little-people/
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Pentagon press secretary to step down in November


WASHINGTON (Reuters) - Pentagon Press Secretary George Little announced on Friday he has decided to step down effective November 15 after two years as the Defense Department's top spokesman and four years in a similar role at the Central Intelligence Agency.


Little said he was leaving so he could spend more time with his family, and that Defense Secretary Chuck Hagel had accepted his decision after they first discussed it last month. He said the search for a successor was under way.


Little served as CIA spokesman under directors Mike Hayden and Leon Panetta. He moved to the Pentagon as chief spokesman when Panetta was named defense secretary to replace Robert Gates. Panetta stepped down as defense secretary earlier this year and was succeeded by Hagel.


Little's announcement came a week after Deputy Defense Secretary Ashton Carter announced that he was leaving in December after four years in senior Pentagon jobs.


(Reporting by David Alexander; Editing by Eric Beech)



Source: http://news.yahoo.com/pentagon-press-secretary-step-down-november-143413528.html
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How The GOP's Shutdown Over Obamacare Fell Short





Susan Cooper (left), of Richardson, Texas, sits with her husband, Jack, 93, as they demonstrate against the government shutdown in Dallas in early October.



Tony Gutierrez/AP


Susan Cooper (left), of Richardson, Texas, sits with her husband, Jack, 93, as they demonstrate against the government shutdown in Dallas in early October.


Tony Gutierrez/AP


Remember how that fight over the budget was all about Obamacare?


Seems like ancient history now, but House Republicans ostensibly shut down the government 17 days ago, demanding first a defunding, and, when that failed, a year's delay in the health law.


When it became clear that President Obama and Senate Democrats weren't going to yield to demands to stop or slow implementation of the administration's signature legislative achievement, Republicans looked for smaller changes.


They floated the idea of killing or delaying an unpopular tax on medical devices. Many Senate Democrats joined Republicans in a nonbinding vote of displeasure on the tax earlier this year.


The Republicans also looked to take away health insurance contributions for congressional and executive branch staffers. And they proposed to delay a temporary $63 annual per-person health insurance tax intended to build a fund to help pay for high-cost cases.


None of those things ended up in the final bill that reopened the federal government and raised the debt ceiling Wednesday night.


So what did?


Well, there was a little language related to the health law. It requires that the Secretary of Health and Human Services "certify to the Congress that the Exchanges verify" that individuals who get subsidies for premiums and cost-sharing are, in fact, eligible. And that the secretary "shall submit a report to the Congress that details the procedures employed by the American Health Benefit Exchanges to verify eligibility for credit and cost-sharing."


Sounds like a big deal? Not really. It so happens that the much-maligned "data hub" that's part of the health exchange already links to the IRS to verify income eligibility. So, basically, the law requires HHS Secretary Sebelius to write a letter explaining what the department is already doing.


But it's not just that the Republicans failed to make any changes to the health law in their 16-day tirade against the government. News coverage of the shutdown and potential default crowded out stories about the very rocky rollout of the health exchanges themselves.


As The Washington Post's Ezra Klein tweeted Wednesday:



Source: http://www.npr.org/blogs/health/2013/10/17/236226848/how-the-gops-shutdown-over-obamacare-fell-short?ft=1&f=1003
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Breitbrat Larry O'Connor: How Dare John McCain Imply Louie Gohmert Is Dumb? (Little green footballs)

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